Effect of zinc concentration in Mueller-Hinton agar on susceptibility of Pseudomonas aeruginosa to meropenem.
نویسنده
چکیده
The susceptibility of Pseudomonas aeruginosa to imipenem has been shown to vary according to zinc concentration in the media. MICs of imipenem for 68 unique clinical isolates of P. aeruginosa were determined in media supplemented with zinc at concentrations between 0.5 and 6.0 micrograms/ml. In agar containing up to 3 micrograms of zinc/ml, 75 to 82% of the strains were susceptible to imipenem at an MIC of < or = 4 micrograms/ml. In agar supplemented to contain 6 micrograms of zinc/ml, however, only 40% of the strains were susceptible to imipenem. Manufacturers should ensure that the concentration of zinc in commercial media is below 3 micrograms/ml to avoid false classification of isolates as resistant to imipenem.
منابع مشابه
The Inhibitory Effect of Zinc on Imipenem and Meropenem Susceptibility of Pseudomonas aeruginosa
393 Abstract: In this study we have showed that zinc ion has an inhibitory activity on imipenem and meropenem suspectibility of Pseudomonas aeruginosa. When zinc ion concentration of Mueller-Hinthon agar (MHA) media was gradually increased the zone diameters of imipenem and meropenem gradually decreased. So we concluded that zinc concentration in the media might effect imipenem and meropenem su...
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عنوان ژورنال:
- Journal of medical microbiology
دوره 47 7 شماره
صفحات -
تاریخ انتشار 1997